منابع مشابه
Levamisole in the treatment of cyclical neutropenia.
A child with cyclical neutropenia was observed before and during treatment with levamisole. Marked clinical improvement occurred while on levamisole. Deterioration occurred after stopping treatment. The improvement was not associated with changes in the neutrophil or monocyte counts, nor did tests of phagocytic cell function convincingly demonstrate improvement while the child was on treatment.
متن کاملA mathematical model of hematopoiesis: II. Cyclical neutropenia.
Cyclical neutropenia is a dynamical disease of the hematopoietic system marked by an oscillation in circulating leukocyte (e.g. neutrophil) numbers to near zero levels and then back to normal. This oscillation is also mirrored in the platelets and reticulocytes which oscillate with the same period. Cyclical neutropenia has an animal counterpart in the grey collie. Using the mathematical model o...
متن کاملOscillations in cyclical neutropenia: new evidence based on mathematical modeling.
We present a dynamical model of the production and regulation of circulating blood neutrophil number. This model is derived from physiologically relevant features of the hematopoietic system, and is analysed using both analytic and numerical methods. Supercritical Hopf bifurcations and saddle-node bifurcations of limit cycles are shown to exist. We make the estimation of kinetic parameters for ...
متن کاملCyclical neutropenia and the peripheral control of white blood cell production.
Cyclical neutropenia (CN) is an interesting dynamic hematological disease in which the neutrophils spontaneously oscillate from approximately normal levels to near zero with a period between 19 and 21 days. In the only known animal model for this disorder, the grey collie, the disease's single apparent difference from human CN is the smaller period of 11-15 days. CN can be treated using the cyt...
متن کاملG-CSF treatment of canine cyclical neutropenia: a comprehensive mathematical model.
OBJECTIVE To study the effects of different G-CSF temporal treatment schemes using a comprehensive mathematical model of the mammalian hematopoietic system that couples the pharmacokinetics of granulocyte colony-stimulating factor (G-CSF) to the hematopoietic stem cell, neutrophil, platelet, and erythrocyte dynamics. MATERIALS AND METHODS Data from cyclical neutropenic (CN) grey collies are u...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1968
ISSN: 0035-9157
DOI: 10.1177/003591576806100345